1. Its primary aim is to develop well-characterized cases of medication-related liver injury on which to conduct hypothesis-driven research targeted at developing means to diagnose, prevent and treat DILI.
2. Nornicotine is produced by the N-demethylation of nicotine during the post-harvest treatment of tobacco leaves. Nornicotine in tobacco serves as the precursor in synthesis of the well-characterized carcinogen N'-nitrosonornicotine, one of the tobacco-specific nitrosamines, and consequently damages the health of tobacco smokers and passive smokers.
3. We employed an easily observable and manipulatable system in which activated and non-activated T-cells were co-cultured with a stable well-characterized clone of lacZ-expressing murine NSCs.
4. For well-characterized minimal-hazard mixtures I will make no more than can be used within a reasonable length of time.